<\/p>\n
ABD Ulusal Halk Radyosu NPR\u2019nin haberine g\u00f6re, Stowers T\u0131bbi Ara\u015ft\u0131rma Enstit\u00fcs\u00fc ara\u015ft\u0131rmac\u0131s\u0131 Randal Halfmann\u2019\u0131n da dahil oldu\u011fu bir grup bilim insan\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rma, hastal\u0131\u011fa yakalananlar\u0131n beyninde \u00f6l\u00fcmc\u00fcl hastal\u0131\u011f\u0131 ilk tetikleyen “molek\u00fcler k\u0131v\u0131lc\u0131m\u0131” bulmay\u0131 hedefledi.<\/p>\n
Hastal\u0131\u011f\u0131n geli\u015fim seyrini, beyinde ger\u00e7ekle\u015fen bir “orman yang\u0131n\u0131”na benzeten Halfmann, “Hastal\u0131k ilerledik\u00e7e, bir t\u00fcr orman yang\u0131n\u0131n\u0131 etkili bir \u015fekilde izliyorsunuz ve bunu neyin ba\u015flatt\u0131\u011f\u0131n\u0131 anlamaya \u00e7al\u0131\u015f\u0131yorsunuz.” dedi.<\/p>\n
Uygulad\u0131klar\u0131 deneme-yan\u0131lma y\u00f6nteminin i\u015fe yarad\u0131\u011f\u0131n\u0131 vurgulayan Halfmann, “beyindeki bu k\u00fc\u00e7\u00fck orman yang\u0131n\u0131n\u0131 ba\u015flatan\u0131n tek bir PolyQ molek\u00fcl\u00fc oldu\u011funu” ifade etti.<\/p>\n
Hastal\u0131\u011fa yakalananlar\u0131n, bedenleri \u00fczerindeki kontrollerini zaman i\u00e7erisinde kaybetmeye ba\u015flad\u0131\u011f\u0131n\u0131 dile getiren Halfmann, hastan\u0131n ya\u015fad\u0131\u011f\u0131 zihinsel fonksiyon kayb\u0131yla devam eden s\u00fcrecin \u00f6l\u00fcmle sonu\u00e7land\u0131\u011f\u0131n\u0131 belirtti.<\/p>\n
Benzeri n\u00f6rolojik dejenerasyon hastal\u0131klar gibi Huntington da beyindeki proteinlerin anormal bir \u015fekle girip birbirine yap\u0131\u015fmas\u0131yla ba\u015fl\u0131yor.<\/p>\n
Bu zararl\u0131 protein y\u0131\u011f\u0131nlar\u0131, \u00e7evresindeki proteinlerin de yanl\u0131\u015f katlanmas\u0131na ve k\u00fcmelenmesine sebebiyet veriyor.<\/p>\n
Beyin h\u00fccrelerini geri d\u00f6n\u00fclmez \u015fekilde yok eden hastal\u0131\u011f\u0131n geli\u015fimi bug\u00fcne kadar engellenememi\u015fken ara\u015ft\u0131rmac\u0131lar hastal\u0131\u011fa sebep olan molek\u00fcl\u00fcn yay\u0131l\u0131m\u0131n\u0131 laboratuvar ortam\u0131nda durdurmay\u0131 ba\u015fard\u0131.<\/p>\n
Huntington hastal\u0131\u011f\u0131nda toksik hale gelen PolyQ adl\u0131 proteinin \u00e7ok say\u0131da versiyonunu olu\u015fturarak h\u00fccrelere yerle\u015ftiren ara\u015ft\u0131rmac\u0131lar, beyin h\u00fccrelerinde meydana gelen katlanma bozukluklar\u0131n\u0131 tespit etmeyi ama\u00e7lad\u0131.<\/p>\n
Halfmann, karanl\u0131k bir odan\u0131n i\u00e7 d\u00fczeni anlamaya benzetti\u011fi metodu, “Bir \u015feylere \u00e7arpmaya devam ediyorsunuz nihayetinde tam olarak (odan\u0131n) neye benzedi\u011fini anlamaya yetecek kadar \u015feye \u00e7arp\u0131yorsunuz.” \u015feklinde anlatt\u0131.<\/p>\n
S\u00f6z konusu metotla laboratuvar ortam\u0131nda bu molek\u00fcl\u00fcn yay\u0131l\u0131m\u0131n\u0131n engellenmesinin yolunu bulduklar\u0131n\u0131 kaydeden Halfmann, bir sonraki ad\u0131m\u0131n ila\u00e7 geli\u015ftirmek oldu\u011funa ifade etti.<\/p>\n
Florida merkezli Wertheim UF Scripps Enstit\u00fcs\u00fc\u2019nde n\u00f6rodejeneratif hastal\u0131klar \u00fczerine \u00e7al\u0131\u015fmalar y\u00fcr\u00fcten Corinne Lasmezas da a\u00e7\u0131klamas\u0131nda, ara\u015ft\u0131rman\u0131n Alzheimer ve Parkinson gibi hastal\u0131klara yol a\u00e7an ilk olguyu bulmaya ve yeni tedavilere kap\u0131 aralayabilece\u011fini belirtti.<\/p>\n