<\/p>\n
The Guardian’\u0131n haberine g\u00f6re, insanlarda aniden ortaya \u00e7\u0131kan k\u0131r\u0131\u015f\u0131kl\u0131klar, a\u011fr\u0131 ve s\u0131z\u0131lardaki art\u0131\u015f ve bir gecede \u00e7\u00f6kme hissinin sebebi 44 ve 60 ya\u015flar\u0131nda ya\u015fanan ya\u015flanma dalgalar\u0131ndan kaynaklan\u0131yor.<\/p>\n
Stanford \u00dcniversitesinde yap\u0131lan ara\u015ft\u0131rmada, kas-iskelet sistemi sorunlar\u0131 ve kardiyovask\u00fcler hastal\u0131klar da dahil olmak \u00fczere ya\u015fla ilgili sa\u011fl\u0131k sorunlar\u0131nda belirli d\u00f6nemlerde ani art\u0131\u015flar meydana geldi\u011fi tespit edildi.<\/p>\n
Ara\u015ft\u0131rmada, 25 ila 75 ya\u015f aras\u0131ndaki 108 g\u00f6n\u00fcll\u00fcden yakla\u015f\u0131k yedi y\u0131l boyunca birka\u00e7 ayda bir kan ve d\u0131\u015fk\u0131 \u00f6rnekleri ile deri, a\u011f\u0131z ve burundan s\u00fcr\u00fcnt\u00fc \u00f6rnekleri al\u0131nd\u0131.<\/p>\n
\u00d6rneklerdeki 135 bin farkl\u0131 molek\u00fcl (RNA, protein ve metabolit) ile mikroorganizmalar (ba\u011f\u0131rsaklar ve deride ya\u015fayan bakteri, vir\u00fcs ve mantarlar) incelendi.<\/p>\n
Ara\u015ft\u0131r\u0131lan molek\u00fcl ve mikroorganizmalardaki de\u011fi\u015fimin kademeli, kronolojik bir \u015fekilde ya\u015fanmad\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc. B\u00fcy\u00fck de\u011fi\u015fimlerin 40’l\u0131 ya\u015flar\u0131n ortalar\u0131nda ve 60’l\u0131 ya\u015flar\u0131n ba\u015flar\u0131nda meydana gelme e\u011filiminde oldu\u011fu tespit edildi.<\/p>\n
Ba\u015flang\u0131\u00e7ta, 40’l\u0131 ya\u015flar\u0131n ortas\u0131ndaki ya\u015flanman\u0131n, t\u00fcm grup i\u00e7in sonu\u00e7lar\u0131 bozan kad\u0131nlardaki perimenopozal de\u011fi\u015fikliklerin bir sonucu oldu\u011fu varsay\u0131ld\u0131. Ancak veriler, 40’l\u0131 ya\u015flar\u0131n ortas\u0131ndaki erkeklerde de benzer de\u011fi\u015fimlerin ya\u015fand\u0131\u011f\u0131n\u0131 ortaya koydu.<\/p>\n
Ara\u015ft\u0131rman\u0131n ba\u015fyazar\u0131, Singapur Nanyang Teknoloji \u00dcniversitesi \u00e7al\u0131\u015fan\u0131 Dr. Xiaotao Shen, 40’l\u0131 ya\u015flar\u0131n ortas\u0131ndaki kad\u0131nlardaki de\u011fi\u015fimlere menopozun katk\u0131da bulunabilece\u011fini kaydederek, “(Ara\u015ft\u0131rma sonu\u00e7lar\u0131) Hem erkeklerde hem de kad\u0131nlarda bu de\u011fi\u015fiklikleri etkileyen muhtemelen ba\u015fka, daha \u00f6nemli fakt\u00f6rler oldu\u011funu g\u00f6steriyor.” ifadelerini kulland\u0131.<\/p>\n
\u0130lk de\u011fi\u015fiklik dalgas\u0131n\u0131n, kardiyovask\u00fcler hastal\u0131klarla ba\u011flant\u0131l\u0131 molek\u00fcllerle, kafein, alkol ile lipitleri metabolize etme yetene\u011finde ya\u015fand\u0131\u011f\u0131, ikincinin ise ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde, karbonhidrat metabolizmas\u0131 ve b\u00f6brek fonksiyonlar\u0131nda g\u00f6r\u00fcld\u00fc\u011f\u00fc tespit edildi.<\/p>\n
Deri ve kas ya\u015flanmas\u0131yla ba\u011flant\u0131l\u0131 molek\u00fcllerde, her iki de\u011fi\u015fim d\u00f6neminde de sorunlar ya\u015fand\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n
Ara\u015ft\u0131rma, ya\u015fa ba\u011fl\u0131 pek \u00e7ok hastal\u0131k riskinin kademeli olarak artmad\u0131\u011f\u0131, Alzheimer ve kardiyovask\u00fcler hastal\u0131k riskinin 60 ya\u015f\u0131ndan sonra h\u0131zland\u0131\u011f\u0131na dair \u00f6nceki ara\u015ft\u0131rmalarla paralellik g\u00f6sterdi.<\/p>\n
\u00d6te yandan, ya\u015fanan baz\u0131 de\u011fi\u015fikliklerin ya\u015fam tarz\u0131 veya davran\u0131\u015fsal fakt\u00f6rlerle ba\u011flant\u0131l\u0131 olabilece\u011fi belirtildi.<\/p>\n
\u00d6rne\u011fin alkol metabolizmas\u0131ndaki de\u011fi\u015fimi, stresli bir d\u00f6nem olan 40’l\u0131 ya\u015flarda alkol t\u00fcketiminin artmas\u0131n\u0131n tetikleyebilece\u011fi \u00f6ne s\u00fcr\u00fcld\u00fc.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, bulgular\u0131n daha h\u0131zl\u0131 kas kayb\u0131 d\u00f6nemlerinde egzersizi art\u0131rmak gibi \u00f6nlemlerin sa\u011fl\u0131\u011f\u0131 koruma konusunda yard\u0131mc\u0131 olabilece\u011fini kaydetti.<\/p>\n
Stanford \u00dcniversitesi Genom Bilimi ve Ki\u015fiselle\u015ftirilmi\u015f T\u0131p Merkezi direkt\u00f6r\u00fc ve ara\u015ft\u0131rman\u0131n k\u0131demli yazar\u0131 Dr. Michael Snyder, “Zaman i\u00e7inde yava\u015f yava\u015f de\u011fi\u015fmiyoruz. 40’l\u0131 ya\u015flar\u0131n ortalar\u0131 ve 60’l\u0131 ya\u015flar\u0131n ba\u015flar\u0131nda, hangi s\u0131n\u0131ftaki molek\u00fcllere bakarsan\u0131z bak\u0131n dramatik bir de\u011fi\u015fim oldu\u011fu ortaya \u00e7\u0131kt\u0131. Hala sa\u011fl\u0131kl\u0131yken ya\u015fam tarz\u0131m\u0131z\u0131 de\u011fi\u015ftirmeye \u00e7al\u0131\u015fmam\u0131z gerekti\u011fine inan\u0131yorum.” de\u011ferlendirmesinde bulundu.<\/p>\n