BE\u00dc Eczac\u0131l\u0131k Fak\u00fcltesi Dr. \u00d6\u011fr. \u00dcyesi G\u00fclay Dilek, T\u0131p Fak\u00fcltesi \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. \u0130shak \u00d6zel Tekin ve Gazi \u00dcniversitesi Fen Fak\u00fcltesi \u00d6\u011fretim \u00dcyesi Prof. Dr. Ali Di\u015fli, tedavide kullan\u0131labilecek ila\u00e7 adaylar\u0131 geli\u015ftirmek i\u00e7in T\u00dcB\u0130TAK 3001 kapsam\u0131nda “Selenotetrazol Halkas\u0131 \u0130\u00e7eren P\u00fcrin Analoglar\u0131” adl\u0131 proje haz\u0131rlad\u0131.<\/p>\n
\u00c7al\u0131\u015fmalarda sentezlenen bile\u015fikler, cilt, over, lenfoma ve ind\u00fcklenmi\u015f periferik kan lenfositleri gibi h\u00fccre hatlar\u0131nda test edildi. Bile\u015fiklerin g\u00fcn\u00fcm\u00fcz kanser tedavisinde kullan\u0131lan 6-merkaptop\u00fcrin bile\u015fi\u011finden daha etkili oldu\u011fu g\u00f6zlemlendi.<\/p>\n
Kemoterapi uygulamalar\u0131nda kullan\u0131lan ve \u015fimdiye kadar p\u00fcrin t\u00fcrevleriyle ilgili yap\u0131lan \u00e7al\u0131\u015fmalarda yap\u0131da \u00e7o\u011funlukla k\u00fck\u00fcrt, azot ya da oksijen i\u00e7eren bile\u015fiklerin bulundu\u011fu g\u00f6r\u00fcld\u00fc.<\/p>\n
Selenyumun da kullan\u0131m\u0131n\u0131 ara\u015ft\u0131ran bu \u00e7al\u0131\u015fmada ortaya \u00e7\u0131kan bile\u015fikler, kemoterapi s\u0131ras\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131k sistemi ve di\u011fer normal dokularda olas\u0131 h\u00fccresel hasar\u0131n restorasyonu i\u00e7in de kullan\u0131labilecek.<\/p>\n
Kanser tedavisinde kullan\u0131lmas\u0131 ama\u00e7lanan ila\u00e7 olmaya aday bu bile\u015fikler, Zonguldak BE\u00dc Teknoloji Transfer Ofisi Koordinat\u00f6rl\u00fc\u011f\u00fcn\u00fcn ba\u015fvurusuyla T\u00fcrk Patent ve Marka Kurumunca tescillendi.<\/p>\n
![\"\"](\"https:\/\/www.aa.com.tr\/uploads\/userFiles\/76bad36d-1411-48e8-a1ae-b65e58872c06\/01.07%2F11%2F20240107_2_62005127_96543276.jpg\"\/)
<\/p>\n
“Sentezledi\u011fimiz bile\u015fikler daha kararl\u0131”<\/h3>\n
Dilek, gazetecilere, bu \u00e7al\u0131\u015fmada selenyum ve tetrazole i\u00e7eren p\u00fcrin t\u00fcrevleri sentezledikleri s\u00f6yledi.<\/p>\n
P\u00fcrin t\u00fcrevleriyle ilgili kemoterapi ila\u00e7lar\u0131n\u0131n mevcut oldu\u011funa de\u011finen Dilek, “Di\u011fer p\u00fcrin t\u00fcrevlerinden fark\u0131 selenyumla ilgili \u00e7al\u0131\u015fmalar \u00e7ok azd\u0131. Selenop\u00fcrin i\u00e7eren bile\u015fikler \u00e7ok karars\u0131z oldu\u011fu i\u00e7in bununla ilgili yap\u0131lan \u00e7al\u0131\u015fmalar \u00fczerine \u00e7ok fazla gidilmemi\u015fti, \u00e7ok etkili olduklar\u0131 halde.” dedi.<\/p>\n
Dilek, sentezledikleri selenop\u00fcrin i\u00e7eren bile\u015fiklerin daha kararl\u0131 oldu\u011funa dikkati \u00e7ekerek, “Biz bu bile\u015fikleri yap\u0131s\u0131nda k\u00fck\u00fcrt bulunan, kemoterapide kullan\u0131lan 6-merkaptopurin ile kar\u015f\u0131la\u015ft\u0131rd\u0131k. Kanser h\u00fccreleri \u00fczerinde ondan \u00e7ok daha fazla etki g\u00f6sterdi\u011fini g\u00f6rd\u00fck. O y\u00fczden de patent almaya karar verdik.” diye konu\u015ftu.<\/p>\n
“\u0130la\u00e7 olabilecek y\u00fcksek potansiyelli \u00fcr\u00fcn\u00fcm\u00fcz var”<\/h3>\n
Tekin de yapt\u0131klar\u0131 ba\u015far\u0131l\u0131 \u00e7al\u0131\u015fmadan mutluluk duyduklar\u0131n\u0131 dile getirerek, “Elde eden \u00fcr\u00fcnlerin 3 de\u011fi\u015fik kanser tipinde etkisini ara\u015ft\u0131rd\u0131k. Cilt kanseri malign melanomda, over kanseri ve lenfomadaki etkilerini \u00e7al\u0131\u015ft\u0131k. Kendi laboratuvar\u0131m\u0131zda hem kanser h\u00fccresi \u00fczerindeki toksit etkilerini hem de DNA sentezine olan etkilerini g\u00f6sterdik.” de\u011ferlendirmesini yapt\u0131.<\/p>\n
Yay\u0131nlar\u0131n\u0131n 2023’te bu alandaki \u00e7al\u0131\u015fmalar aras\u0131nda dikkat \u00e7ekti\u011fine de\u011finen Tekin, “Mevcut ila\u00e7lara alternatif olabilecek yeni molek\u00fcller aras\u0131nda yer ald\u0131. Bu da bize \u00fcmit verdi. Evet \u015fu an bir ilac\u0131m\u0131z yok ama ila\u00e7 olabilecek y\u00fcksek potansiyelli \u00fcr\u00fcn\u00fcm\u00fcz var ve bu \u00fcr\u00fcn\u00fcn tasarlanmas\u0131 ve deneylerin yap\u0131lmas\u0131 G\u00fclay Hocam\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcnde ger\u00e7ekle\u015fti.” ifadelerini kulland\u0131.<\/p>\n
Tekin, patent s\u00fcrecinin \u00e7ok zorlu ge\u00e7ti\u011fini vurgulayarak, s\u00f6zlerini, “4 y\u0131l\u0131n sonras\u0131nda onay\u0131m\u0131z geldi ama sonu\u00e7tan mutluyuz. \u00c7\u00fcnk\u00fc d\u00fcnyada selena tetrazole halkas\u0131yla yap\u0131lm\u0131\u015f b\u00f6yle \u00fcr\u00fcn yok. G\u00fclay Hocan\u0131n sentezledi\u011fi d\u0131\u015f\u0131nda ve olduk\u00e7a da etkin. Gelecek vadeden ilaca d\u00f6n\u00fc\u015fme potansiyeli y\u00fcksek bir t\u00fcrev oldu\u011funu d\u00fc\u015f\u00fcn\u00fcyoruz.” diye tamamlad\u0131.<\/p>\n