<\/p>\n
Erciyes \u00dcniversitesi (ER\u00dc) Biyomedikal M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc Dr. \u00d6\u011fr. \u00dcyesi Yavuz Nuri Erta\u015f, kanserli farelere X \u0131\u015f\u0131nlar\u0131na ilave olarak ak\u0131ll\u0131 “nanopar\u00e7ac\u0131klar” ile uygulad\u0131\u011f\u0131 radyoterapide olumlu sonu\u00e7 elde etmeyi ba\u015fard\u0131.<\/p>\n
Biyomedikal m\u00fchendisli\u011fi ve nanoteknoloji alanlar\u0131nda Ba\u015fkent ve Bilkent \u00fcniversitelerinde e\u011fitimini tamamlayan Erta\u015f, daha sonra doktora e\u011fitimi i\u00e7in Kaliforniya \u00dcniversitesi-Los Angeles’dan tam bursa hak kazanarak ABD’ye gitti.<\/p>\n
Doktora e\u011fitiminin ard\u0131ndan iki y\u0131l doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 olarak \u00e7al\u0131\u015fan Erta\u015f, 2020 y\u0131l\u0131 ba\u015f\u0131nda T\u00dcB\u0130TAK’\u0131n 2232-Uluslararas\u0131 Lider Ara\u015ft\u0131rmac\u0131lar Program\u0131 kapsam\u0131nda T\u00fcrkiye’ye d\u00f6nd\u00fc.<\/p>\n
“Nanopar\u00e7ac\u0131klar ve biyomalzeme ile doku yenilenmesi” \u00fczerine meme kanseri tedavisi \u00e7al\u0131\u015fmalar\u0131 yapan Erta\u015f, kanserli farelere X \u0131\u015f\u0131nlar\u0131na ilave olarak ak\u0131ll\u0131 “nanopar\u00e7ac\u0131klar” ile uygulad\u0131\u011f\u0131 radyoterapide olumlu sonu\u00e7 elde etti.<\/p>\n
ER\u00dc Biyomedikal M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc Dr. \u00d6\u011fr. \u00dcyesi Erta\u015f, AA muhabirine, ABD’den \u00fclkesine hizmet etmek i\u00e7in d\u00f6nd\u00fc\u011f\u00fcn\u00fc s\u00f6yledi.<\/p>\n
\u00dclkeye d\u00f6nd\u00fc\u011f\u00fcnde, devletin laboratuvar, \u00f6\u011frenci bursu ve ara\u015ft\u0131rmalar i\u00e7in destek verdi\u011fini anlatan Erta\u015f, nanoteknoloji tedavi y\u00f6ntemiyle, bu y\u0131l dokuzuncusu d\u00fczenlenen T\u00fcrk T\u0131p D\u00fcnyas\u0131 Kurultay\u0131’nda 2023 T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) Te\u015fvik \u00d6d\u00fcl\u00fc ald\u0131\u011f\u0131n\u0131 an\u0131msatt\u0131.<\/p>\n
T\u00fcrkiye’de her y\u0131l 5 ki\u015fiye verilen \u00f6d\u00fcl\u00fc, “nanopar\u00e7ac\u0131klar ve biyomalzeme ile doku yenilenmesi” \u00fczerine meme kanseri tedavisi \u00e7al\u0131\u015fmalar\u0131 sonucunda ald\u0131\u011f\u0131n\u0131 belirten Erta\u015f, \u00f6d\u00fcl\u00fc alan ilk biyomedikal m\u00fchendisi oldu\u011funu ifade etti.<\/p>\n
Kanser hastalar\u0131na ameliyat, kemoterapi ve radyoterapi ile tedavi uyguland\u0131\u011f\u0131na de\u011finen Erta\u015f, radyoterapinin en b\u00fcy\u00fck s\u0131k\u0131nt\u0131lar\u0131ndan birinin X \u0131\u015f\u0131n\u0131n\u0131n ge\u00e7ti\u011fi sa\u011fl\u0131kl\u0131 b\u00f6lgelerdeki dokular\u0131 da yava\u015f yava\u015f bozmas\u0131 ve bunun kilo kayb\u0131, sa\u00e7 d\u00f6k\u00fclmesi ya da farkl\u0131 deri hastal\u0131klar\u0131 gibi \u00e7ok say\u0131da yan etkiye yol a\u00e7mas\u0131 oldu\u011funu dile getirdi.<\/p>\n
Kanser hastalar\u0131nda X \u0131\u015f\u0131n\u0131n\u0131n dozunun \u00f6nemli oldu\u011funu vurgulayan Erta\u015f, “Deneyimizde meme kanseri \u00e7al\u0131\u015ft\u0131k ama farkl\u0131 kanser t\u00fcrlerinde de bu \u00e7al\u0131\u015fma denenebilir. Mesela mide, ba\u011f\u0131rsak ve karaci\u011fer kanseri gibi. \u00c7al\u0131\u015fman\u0131n \u00f6zelinde bu nanopar\u00e7ac\u0131klar\u0131 kanserli b\u00f6lgenin etraf\u0131na g\u00f6nderdik. Bunlar v\u00fccuda enjeksiyon y\u00f6ntemiyle verildikten sonra ak\u0131ll\u0131 nanopar\u00e7ac\u0131klar\u0131 kanserli b\u00f6lgeyi tan\u0131yacak \u015fekilde dizayn edip, kanserli doku etraf\u0131nda k\u00fcmelenmesini sa\u011flad\u0131k. Sonra harici X \u0131\u015f\u0131n\u0131n\u0131 verirken de 5 birim veriyorsak, 2 birim vererek ayn\u0131 i\u015fi daha az yan etki ile daha etkili sonuca ula\u015ft\u0131rmaya \u00e7al\u0131\u015ft\u0131k.” diye konu\u015ftu.<\/p>\n
Fare deneylerinin sonu\u00e7lar\u0131 hakk\u0131nda bilgi veren Erta\u015f, \u015f\u00f6yle devam etti:<\/p>\n
“Deneylerde (farelere) hi\u00e7bir \u015fey vermedi\u011fimizde, t\u00fcm\u00f6rl\u00fc doku bir ayda 4-5 kat\u0131na \u00e7\u0131kabiliyor. Sadece X \u0131\u015f\u0131n\u0131 verdi\u011fimizde, t\u00fcm\u00f6r\u00fcn artma h\u0131z\u0131 azal\u0131yor, tamamen elimine olmuyor ama spesifik oranlarda nanopar\u00e7ac\u0131k enjeksiyonu ve X \u0131\u015f\u0131\u011f\u0131 verildi\u011finde, t\u00fcm\u00f6rlerin boyutlar\u0131 ya sabit tutulabiliyor ya da baz\u0131 farelerde ciddi oranda azal\u0131yor, hatta baz\u0131 deney gruplar\u0131nda t\u00fcm\u00f6r\u00fcn tamamen elimine edildi\u011fini g\u00f6rd\u00fck. Bu \u00e7al\u0131\u015fmalar d\u00fcnyan\u0131n \u00f6nde gelen sayg\u0131n bilimsel dergilerinde yay\u0131mland\u0131.”<\/p>\n
Erta\u015f, cerrahi y\u00f6ntemle t\u00fcm\u00f6r\u00fcn al\u0131nd\u0131\u011f\u0131 b\u00f6lgedeki dokularda mikro seviyede kanserli h\u00fccre gruplar\u0131n\u0131n kalabildi\u011fini, bu h\u00fccrelerin 3-5 sene sonra metastaz (yay\u0131lma) yapabildi\u011fini belirterek, uygulad\u0131klar\u0131 nanoteknolojinin mikro seviyedeki t\u00fcm\u00f6rl\u00fc dokular\u0131 da \u00f6ld\u00fcrd\u00fc\u011f\u00fcn\u00fc ve yay\u0131lma riskinin ortadan kalkt\u0131\u011f\u0131n\u0131 dile getirdi.<\/p>\n
Fare deneylerinin ard\u0131ndan yak\u0131n zamanda klinik deneylerine ge\u00e7eceklerini anlatan Erta\u015f, tedavide kullan\u0131lan nanoteknoloji hakk\u0131nda \u015fu bilgileri verdi:<\/p>\n
“Kulland\u0131\u011f\u0131m\u0131z nanopar\u00e7ac\u0131klar\u0131n boyutlar\u0131 bir sa\u00e7 telinin kal\u0131nl\u0131\u011f\u0131n\u0131n yakla\u015f\u0131k 1000’de 1’i civar\u0131nda ve metalik yap\u0131da. Neden metalik yap\u0131da? X \u0131\u015f\u0131\u011f\u0131 metale vurdu\u011fu zaman sa\u00e7\u0131lan elektronlar, h\u00fccrede de\u011fi\u015fik molek\u00fcller \u00fcretiyor ve bu molek\u00fcller h\u00fccreyi \u00f6ld\u00fcr\u00fcyor. Bu y\u00fczden par\u00e7ac\u0131klar\u0131 metal yap\u0131da \u00fcretiyoruz \u00e7\u00fcnk\u00fc \u00e7ok fazla elektron sa\u00e7mas\u0131n\u0131 istiyoruz. X \u0131\u015f\u0131n\u0131 verildi\u011finde bu sa\u00e7\u0131lan elektronlarla daha fazla kanser h\u00fccresini \u00f6ld\u00fcrmek istiyoruz.”<\/p>\n