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TURKOVAC a\u015f\u0131s\u0131n\u0131 geli\u015ftiren Prof. Dr. Aykut \u00d6zdarendeli, K\u0131r\u0131m Kongo Kanamal\u0131 Ate\u015fi (KKKA) hastal\u0131\u011f\u0131na kar\u015f\u0131 daha iyi sonu\u00e7 veren ve \u00fcretimi cans\u0131z vir\u00fcs veya bakteri a\u015f\u0131lar\u0131na (inaktif) k\u0131yasla daha kolay olan yeni a\u015f\u0131 i\u00e7in klinik \u00f6ncesi \u00e7al\u0131\u015fmalara ba\u015flad\u0131klar\u0131n\u0131 s\u00f6yledi.<\/p>\n
Erciyes \u00dcniversitesi A\u015f\u0131 Ara\u015ft\u0131rma ve Geli\u015ftirme Uygulama ve Ara\u015ft\u0131rma Merkezi (ERAGEM) M\u00fcd\u00fcr\u00fc \u00d6zdarendeli, AA muhabirine, 2002’de ilk kez bir hastaya KKKA te\u015fhisi konuldu\u011funu, ilkbahar, yaz aylar\u0131nda \u00f6zellikle “Kelkit Vadisi” denilen b\u00f6lgedeki kentlerde kene tutunmas\u0131 sonucu ortaya \u00e7\u0131kan hastal\u0131\u011f\u0131n \u00e7ok say\u0131da \u015fehirde yay\u0131ld\u0131\u011f\u0131n\u0131 anlatt\u0131.<\/p>\n
KKKA vakalar\u0131n\u0131n en \u00e7ok g\u00f6r\u00fcld\u00fc\u011f\u00fc \u00fclkenin T\u00fcrkiye oldu\u011funa dikkati \u00e7eken \u00d6zdarendeli, vaka g\u00f6r\u00fclmeyen \u00fclkelerde de a\u015f\u0131 ara\u015ft\u0131rma \u00e7al\u0131\u015fmalar\u0131 yap\u0131ld\u0131\u011f\u0131n\u0131 aktard\u0131.<\/p>\n
T\u00fcrkiye’nin KKKA hastal\u0131\u011f\u0131na \u00e7are bulmas\u0131 gerekti\u011fini vurgulayan \u00d6zdarendeli, \u015f\u00f6yle konu\u015ftu:<\/p>\n
“2006’dan bu yana KKKA hastal\u0131\u011f\u0131yla ilgili \u00e7al\u0131\u015fmalar yap\u0131yoruz. Sona do\u011fru yakla\u015f\u0131yoruz, iyi \u015feyler olacak diye d\u00fc\u015f\u00fcn\u00fcyorum. 2023 May\u0131s sonu itibar\u0131yla \u00e7al\u0131\u015fmalara ba\u015flad\u0131k. 3 seneye yak\u0131n ara vermi\u015ftik. Bir T\u00dcB\u0130TAK projesi bitirmi\u015ftik, 1003 projesi ve onun devam\u0131 \u015feklinde de T\u00dcSEB (T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131) projemiz \u00e7\u0131kt\u0131, may\u0131stan itibaren y\u00fcr\u00fcrl\u00fc\u011fe girdi proje. TURKOVAC’tan dolay\u0131 ara verdi\u011fimiz \u00e7al\u0131\u015fmalara ba\u015flad\u0131k.<\/p>\n
Rekombinant (vir\u00fcs DNA’s\u0131 yeniden d\u00fczenlenmi\u015f) bir a\u015f\u0131 \u00fczerine \u00e7al\u0131\u015f\u0131yoruz \u015fu anda. Preklinik (klinik \u00f6ncesi) \u00e7al\u0131\u015fmalar belirli bir noktaya geldi. Ayn\u0131 zamanda T\u00dcSEB’in destekledi\u011fi ve \u00f6zel sekt\u00f6rle birlikte TURKOVAC’\u0131 ba\u015far\u0131yla \u00fcreten Dollvet ile i\u015fbirli\u011fimiz var. Bu noktada da projenin sonuna geldi\u011fimizde preklinik \u00e7al\u0131\u015fmalar\u0131n hemen hemen hepsi tamamlanm\u0131\u015f olacak. \u0130yi sonu\u00e7lar elde edildi\u011fi takdirde de Faz-1 \u00e7al\u0131\u015fmalar\u0131na ge\u00e7meyi umut ediyoruz.”<\/p>\n
KKKA hastal\u0131\u011f\u0131yla m\u00fccadelede farkl\u0131 bir a\u015f\u0131 platformuna y\u00f6neldiklerini belirten Prof. Dr. \u00d6zdarendeli, \u015funlar\u0131 kaydetti:<\/p>\n
“\u0130naktif a\u015f\u0131 \u00fcretilmesine y\u00f6nelik \u00e7al\u0131\u015fmada Faz-1 noktas\u0131na gelmi\u015ftik ama \u015fimdi rekombinant bir a\u015f\u0131 platformumuz var. Bunun klinik \u00f6ncesi verilerinde inaktif a\u015f\u0131dan daha y\u00fcksek, daha iyi sonu\u00e7lar al\u0131nd\u0131. Bu noktada rekombinant a\u015f\u0131ya y\u00f6nelmeye karar verdik \u00e7\u00fcnk\u00fc veriler \u00e7ok daha g\u00fczel. Di\u011feri de gayet g\u00fczeldi ama buradaki veriler daha g\u00fczel, \u00fcretimi daha kolay.”<\/p>\n
\u00d6zdarendeli, Kovid-19’a kar\u015f\u0131 geli\u015ftirilen TURKOVAC ile ilgili \u00e7al\u0131\u015fmalar\u0131 tamamlad\u0131klar\u0131n\u0131, \u00e7ok g\u00fczel neticeler al\u0131nd\u0131\u011f\u0131n\u0131, y\u0131llar sonra T\u00fcrkiye’de ilk be\u015feri a\u015f\u0131 \u00fcretiminin ger\u00e7ekle\u015ftirildi\u011fini hat\u0131rlatarak, payda\u015flara te\u015fekk\u00fcr etti.<\/p>\n
A\u015f\u0131 merkezi olarak Kovid-19’un varyantlar\u0131na kar\u015f\u0131 ara\u015ft\u0131rmalar\u0131n\u0131n s\u00fcrd\u00fc\u011f\u00fcn\u00fc anlatan \u00d6zdarendeli, “Kovid ile ilgili SARS-CoV-2 vir\u00fcs\u00fcyle ilgili \u00e7al\u0131\u015fmalar\u0131m\u0131z devam ediyor. Belki a\u015f\u0131 baz\u0131nda de\u011fil ama ara\u015ft\u0131rma baz\u0131nda devam etti\u011fimiz \u00e7al\u0131\u015fmalar var. Omicron varyantlar\u0131 g\u00fcncel \u015fu anda. Bu varyantlara kar\u015f\u0131 izolasyonlar\u0131m\u0131z var, birtak\u0131m varyantlara kar\u015f\u0131 etkinlik \u00e7al\u0131\u015fmalar\u0131m\u0131z devam ediyor.” ifadelerini kuland\u0131.<\/p>\n