<\/p>\n
Serkan K\u0131r ve ekibi, 6 y\u0131l boyunca kanserle birlikte geli\u015fen, \u00f6zellikle hastal\u0131\u011f\u0131n ileri evrelerinde s\u0131k rastlanan, tedaviyi ve ya\u015fam kalitesini olumsuz etkileyen kilo ve kas kayb\u0131n\u0131 nas\u0131l \u00f6nleyebilecekleri \u00fczerine \u00e7al\u0131\u015ft\u0131.<\/p>\n
S\u00fcre\u00e7te “EDA2R” geni ile “NIK” enziminin kilo ve kas kayb\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 g\u00f6zlemleyen ekip, bunlar\u0131 devre d\u0131\u015f\u0131 b\u0131rakt\u0131klar\u0131nda kilo ve kas kayb\u0131n\u0131n da \u00f6nlenebildi\u011fini ke\u015ffetti.<\/p>\n
Ara\u015ft\u0131rman\u0131n “EDA2R\u2013NIK signalling promotes muscle atrophy linked to cancer cachexia” adl\u0131 makalesi, \u00fcst d\u00fczey bilimsel \u00e7al\u0131\u015fmalara yer verilen uluslararas\u0131 hakemli dergi “Nature”da yay\u0131mland\u0131. B\u00f6ylece, K\u0131r ve ekibinin bu \u00e7al\u0131\u015fmas\u0131 d\u00fcnya t\u0131bb\u0131nda umut vadeden \u00e7al\u0131\u015fma olarak kabul g\u00f6rm\u00fc\u015f oldu.<\/p>\n
Dr. \u00d6\u011fretim \u00dcyesi Serkan K\u0131r, AA muhabirine, kanser hastalar\u0131n\u0131n bir\u00e7o\u011funda ortaya \u00e7\u0131kan a\u015f\u0131r\u0131 kilo kayb\u0131 ve buna ba\u011fl\u0131 kas kayb\u0131n\u0131n sebeplerinin tam olarak bilinmedi\u011fini, bu konu \u00fczerine ara\u015ft\u0131rmalar\u0131n hala s\u00fcrd\u00fc\u011f\u00fcn\u00fc s\u00f6yledi.<\/p>\n
V\u00fccudun b\u00fct\u00fcn\u00fcnde geli\u015fen enflamasyonun bu s\u00fcre\u00e7te \u00f6nemli rol oynad\u0131\u011f\u0131n\u0131n, t\u00fcm\u00f6rlerin salg\u0131lad\u0131\u011f\u0131 hormon benzeri baz\u0131 proteinlerin ka\u015feksi ile kas kayb\u0131n\u0131 uyard\u0131\u011f\u0131n\u0131n d\u00fc\u015f\u00fcn\u00fcld\u00fc\u011f\u00fcn\u00fc anlatan K\u0131r, t\u00fcm\u00f6r geli\u015fimini destekledi\u011fine dair a\u00e7\u0131k bir kan\u0131t bulunmayan ka\u015feksi ile beraber ya\u011f ve kas dokular\u0131ndan sal\u0131nan ya\u011f ve protein yap\u0131 ta\u015flar\u0131n\u0131n t\u00fcm\u00f6r b\u00fcy\u00fcmesine katk\u0131 sa\u011flad\u0131\u011f\u0131n\u0131n d\u00fc\u015f\u00fcn\u00fcld\u00fc\u011f\u00fcn\u00fc belirtti.<\/p>\n
Serkan K\u0131r, ka\u015feksi durumunda t\u00fcm\u00f6rlerin hasta metabolizmas\u0131nda verimsizli\u011fe yol a\u00e7arak enerji israf\u0131na neden oldu\u011funu kaydetti.<\/p>\n
Bu durumun kilo kayb\u0131n\u0131 beraberinde getirdi\u011fini aktaran K\u0131r, “Ka\u015feksi, hastalar\u0131n ya\u015fam kalitesini ve hayatta kalma s\u00fcresini olumsuz etkiliyor. Hastalar, \u00f6zellikle kas kayb\u0131, halsizlik ve g\u00fc\u00e7s\u00fczl\u00fck gibi problemler ya\u015f\u0131yorlar ve ya\u015fam kaliteleri g\u00fcndelik ihtiya\u00e7lar\u0131n\u0131 gideremeyecek \u015fekilde azalabiliyor. Kilo kayb\u0131, hastalara uygulanan kemoterapi gibi tedavilere cevap vermeyi engelliyor ve ne yaz\u0131k ki hastal\u0131\u011f\u0131n son evrelerinde tedavinin sonland\u0131r\u0131lmas\u0131na neden oluyor.” dedi.<\/p>\n
Dr. \u00d6\u011fretim \u00dcyesi K\u0131r, a\u015f\u0131r\u0131 kilo kayb\u0131n\u0131n tedavisine y\u00f6nelik \u015fimdilik etkili bir ila\u00e7 bulunmad\u0131\u011f\u0131n\u0131, \u00f6zellikle kas kayb\u0131n\u0131 \u00f6nlemeye ili\u015fkin klinik denemeleri devam eden ila\u00e7lardan da hen\u00fcz ba\u015far\u0131l\u0131 sonu\u00e7lar elde edilemedi\u011fini belirtti. <\/p>\n
Kilo kaybeden hastalara uygulanan besin takviyesi gibi tedavilerin de bu duruma engel olamad\u0131\u011f\u0131na dikkati \u00e7eken K\u0131r, yeni ila\u00e7 tasarlanmas\u0131na hizmet edecek her t\u00fcrl\u00fc bilimsel ara\u015ft\u0131rman\u0131n ka\u015feksi i\u00e7in \u00e7ok b\u00fcy\u00fck \u00f6nem ta\u015f\u0131d\u0131\u011f\u0131n\u0131 ifade etti. <\/p>\n
Serkan K\u0131r, ara\u015ft\u0131rmalar\u0131nda yola \u00e7\u0131k\u0131\u015f ve odak noktalar\u0131n\u0131 ise \u015f\u00f6yle anlatt\u0131:<\/p>\n
“Ara\u015ft\u0131rmam\u0131z iki farkl\u0131 mekanizma \u00fczerine yo\u011funla\u015fm\u0131\u015f durumda. Fareler \u00fczerinde ger\u00e7ekle\u015ftirdi\u011fimiz t\u00fcm\u00f6r ekimi deneyleri, kas dokusunda bu iki mekanizman\u0131n aktifle\u015fti\u011fine dair belirtiler sunuyor. \u00c7al\u0131\u015fmam\u0131zda bu mekanizmalarda g\u00f6rev alan proteinlerin fonksiyonlar\u0131na odakland\u0131k. Kas h\u00fccre k\u00fclt\u00fcr\u00fcnde ger\u00e7ekle\u015ftirdi\u011fimiz deneylerimiz bu mekanizman\u0131n uyar\u0131lmas\u0131 durumunda h\u00fccrelerde ciddi derecede k\u00fc\u00e7\u00fclme meydana geldi\u011fini g\u00f6sterdi. Ayr\u0131ca bu mekanizmalar\u0131n farelerin kas dokular\u0131nda aktifle\u015fmesi de yine kas k\u00fctlesinde azalmaya neden olmaktad\u0131r. Bu sonu\u00e7lar, t\u00fcm\u00f6rler taraf\u0131ndan uyar\u0131lmas\u0131 durumunda bu mekanizmalar\u0131n kas kayb\u0131nda do\u011frudan rol alabilece\u011fini g\u00f6steriyor.” <\/p>\n
Bu konuyla ilgili ara\u015ft\u0131rmalar\u0131na yurt d\u0131\u015f\u0131ndaki \u00e7al\u0131\u015fmalar\u0131n\u0131 tamamlay\u0131p 2017’de T\u00fcrkiye’ye d\u00f6nd\u00fc\u011f\u00fcnde ba\u015flad\u0131\u011f\u0131n\u0131 anlatan K\u0131r, ara\u015ft\u0131rman\u0131n yakla\u015f\u0131k 6 y\u0131l s\u00fcrd\u00fc\u011f\u00fcn\u00fc dile getirdi.<\/p>\n
Dr. \u00d6\u011fretim \u00dcyesi K\u0131r, \u00e7al\u0131\u015fmay\u0131 4 doktora \u00f6\u011frencisi, 1 doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 ve 1 lisans \u00f6\u011frencisi olmak \u00fczere 7 ki\u015filik ekiple birlikte s\u00fcrd\u00fcrd\u00fcklerini belirterek, yay\u0131nlanan bilimsel makalenin birinci yazarlar\u0131ndan da olan doktora \u00f6\u011frencileri \u015eevval Nur Bilgi\u00e7 ve Aylin Domaniku’nun ara\u015ft\u0131rmada en \u00e7ok sorumluluk alan \u00f6\u011frenciler oldu\u011funu vurgulad\u0131.<\/p>\n
Kanser hastalar\u0131ndan toplanan dokular\u0131n incelenmesi i\u00e7in Bel\u00e7ikal\u0131 3 bilim insan\u0131n\u0131n da \u00e7al\u0131\u015fmaya dahil edildi\u011fini aktaran K\u0131r, \u00e7al\u0131\u015fmada kanser hastalar\u0131n\u0131n kas biyopsi \u00f6rneklerinin incelendi\u011fini, k\u00fclt\u00fcrlenmi\u015f kas h\u00fccrelerinde molek\u00fcler d\u00fczeyde deneyler ger\u00e7ekle\u015ftirildi\u011fini, geneti\u011fi de\u011fi\u015ftirilmi\u015f (transgenik) fareler \u00fczerinde t\u00fcm\u00f6r ekimi deneyleri yap\u0131ld\u0131\u011f\u0131n\u0131 bildirdi.<\/p>\n
Dr. \u00d6\u011fretim \u00dcyesi Serkan K\u0131r, ara\u015ft\u0131rmada elde ettikleri bulgular\u0131n, t\u00fcm\u00f6r\u00fcn varl\u0131\u011f\u0131 durumunda “OSM” ve “EDA2R” proteinlerini i\u00e7eren iki farkl\u0131 mekanizman\u0131n kas dokusunda aktifle\u015fti\u011fini, bu mekanizmalar\u0131n ikisinin de kas kayb\u0131n\u0131 do\u011frudan uyarabildi\u011fini g\u00f6sterdi\u011fini anlatt\u0131. <\/p>\n
Sonu\u00e7larda kas dokusunda birbirlerini de uyarabilen bu mekanizmalar\u0131n kas kayb\u0131n\u0131 daha da dramatik hale getirdi\u011fine dikkati \u00e7eken K\u0131r, mekanizmada yer alan hormon benzeri bir proteinin, kansere ba\u011fl\u0131 olarak kanda art\u0131\u015f g\u00f6stermesiyle kas dokusu \u00fczerindeki etkisinin tetiklendi\u011fini g\u00f6zlemlediklerini aktard\u0131. <\/p>\n
Serkan K\u0131r, geneti\u011fi de\u011fi\u015ftirilmi\u015f ve mekanizma genlerinin (OSM, EDA2R ve NIK) ortadan kald\u0131r\u0131ld\u0131\u011f\u0131 farelerde yap\u0131lan t\u00fcm\u00f6r ekimi \u00e7al\u0131\u015fmalar\u0131n\u0131n ise bu mekanizmalar\u0131n kas kayb\u0131nda \u00f6nemli roller \u00fcstlendi\u011fini g\u00f6sterdi\u011fine de\u011findi. <\/p>\n
Mekanizma genlerinin yoklu\u011funda, farelerin t\u00fcm\u00f6rlere ba\u011fl\u0131 kas kayb\u0131na kar\u015f\u0131 diren\u00e7 kazanmay\u0131 ba\u015fard\u0131\u011f\u0131ndan bahseden K\u0131r, “\u00c7al\u0131\u015fmam\u0131zda kas kayb\u0131nda rol alan yeni molek\u00fcler mekanizmalar ke\u015ffettik. Takip eden ara\u015ft\u0131rma projelerimizde bu mekanizmalarda g\u00f6rev alan proteinleri hedefleyerek kas kayb\u0131n\u0131n \u00f6nlenmesini ama\u00e7l\u0131yoruz.” dedi. <\/p>\n
Serkan K\u0131r, geneti\u011fi de\u011fi\u015ftirilmi\u015f fareler \u00fczerinde yap\u0131lan deneylerin tamamland\u0131\u011f\u0131n\u0131 kaydetti. <\/p>\n
Bundan sonraki a\u015famalarda ke\u015ffedilen mekanizmalar\u0131 hedefleyen ila\u00e7lar\u0131n geli\u015ftirilece\u011finin alt\u0131n\u0131 \u00e7izen K\u0131r, “Bunlar \u00f6ncelikle t\u00fcm\u00f6rl\u00fc farelerde test edilecek. Ondan sonraki s\u00fcre\u00e7, tedavi ara\u00e7lar\u0131n\u0131n klinik \u00e7al\u0131\u015fmalarla kanser hastalar\u0131 \u00fczerinde denenmesinden olu\u015fuyor.” bilgisini verdi. <\/p>\n
Dr. \u00d6\u011fretim \u00dcyesi K\u0131r, ara\u015ft\u0131rmalar\u0131n\u0131n T\u00fcrkiye’ye ve d\u00fcnyaya sunaca\u011f\u0131 katk\u0131ya y\u00f6nelik \u015fu de\u011ferlendirmelerde bulundu:<\/p>\n
“\u00c7al\u0131\u015fmam\u0131z, kansere ba\u011fl\u0131 kas kayb\u0131n\u0131 tetikleyen iki yeni mekanizmay\u0131 ayd\u0131nlatt\u0131. Elde edilen yeni bilgilerle tedavi ara\u00e7lar\u0131n\u0131n geli\u015ftirilmesine katk\u0131da bulunmu\u015f olduk. Bu bilgilerle t\u00fcm d\u00fcnyada yeni \u00e7\u00f6z\u00fcmlerin yayg\u0131nla\u015fmas\u0131 da muhtemel g\u00f6r\u00fcn\u00fcyor. Ke\u015ffetti\u011fimiz mekanizmalar\u0131n ba\u015fka hangi g\u00f6revleri oldu\u011funa dair \u00e7al\u0131\u015fmaya devam ediyoruz. \u00c7al\u0131\u015fman\u0131n farkl\u0131 kas hastal\u0131klar\u0131 ve ya\u015flanmaya ba\u011fl\u0131 kas kayb\u0131 s\u00fcre\u00e7lerinde de aktif rol alaca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyor. Hedeflerimiz aras\u0131nda bu mekanizmalar\u0131n kansere ba\u011fl\u0131 kilo ve kas kayb\u0131 d\u0131\u015f\u0131nda ya\u015flanma ve tip 1 diyabete ba\u011fl\u0131 kas kay\u0131plar\u0131ndaki rollerini incelemek de bulunuyor.” <\/p>\n
Serkan K\u0131r, bu alanda var olan bilgi eksikli\u011finin giderilmesinin \u00e7al\u0131\u015fmalar\u0131n\u0131n d\u00fcnyan\u0131n en \u00f6nemli bilim dergilerinden biri olan Nature’da yer almas\u0131n\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 belirterek, “Ba\u015ftan sona T\u00fcrkiye’de y\u00fcr\u00fct\u00fclm\u00fc\u015f, Ko\u00e7 \u00dcniversitesi \u00e7at\u0131s\u0131 alt\u0131nda ger\u00e7ekle\u015ftirilmi\u015f bir ara\u015ft\u0131rman\u0131n Nature’da yay\u0131mlanmas\u0131 hem bizler hem de \u00fclkemiz a\u00e7\u0131s\u0131ndan bir gurur kayna\u011f\u0131. \u00c7al\u0131\u015fmam\u0131z\u0131n T\u00fcrkiye ve d\u00fcnyada y\u00fcr\u00fct\u00fclecek daha fazla ara\u015ft\u0131rmaya ilham olmas\u0131n\u0131 umuyoruz.” \u015feklinde konu\u015ftu.<\/p>\n